Radiation Therapy Target Objectives for Tonsillar Cancer Treated With Unilateral Radiation Therapy—a Replanning Study From TROG 12.01

G Osbourne; A Devlin; N Walsh; N Hardcastle; A Moore; D Rischin; L Kenny; S Porceddu; C Wratten; A Macann; JE Jackson; J Corry; L McDowell

Journal article

Radiation Therapy Target Objectives for Tonsillar Cancer Treated With Unilateral Radiation Therapy—a Replanning Study From TROG 12.01

G Osbourne, A Devlin, N Walsh, N Hardcastle, A Moore, D Rischin, L Kenny, S Porceddu, C Wratten, A Macann, JE Jackson, J Corry, L McDowell

International Journal of Radiation Oncology Biology Physics | Published : 2026

DOI: 10.1016/j.ijrobp.2025.12.058

Abstract

PurposeUnilateral radiation therapy (URT) is an effective treatment strategy in selected patients with lateralized tonsil cancer. However, there is a lack of established planning guidelines for URT treatment, leading to suboptimal optimization of contralateral and midline organs at risk (OARs). This study aimed to reoptimize URT plans to maximize sparing of midline and contralateral OAR’s while maintaining target coverage, providing dosimetric guidelines for URT planning.Methods and MaterialsTreatment plan data for patients treated with URT on TROG 12.01 were reoptimized using Eclipse V16.01. All relevant midline and OAR contours were contoured to align with international OAR consensus guide..

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